Rabeprazole inhibits gastric acid secretion by selectively blocking the H⁺/K⁺-H/K-ATPase enzyme system (“proton pump”) of gastric parietal cells, leading to potent and sustained reduction of gastric acidity.
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Proper Packaging
Rabeca is indicated for:
Duodenal/Gastric Ulcer: 20 mg once daily for 4–6 weeks.
GERD (erosive/ulcerative): 20 mg once daily for 4–8 weeks.
GERD Maintenance: 10–20 mg once daily as needed.
Symptomatic GERD: 10 mg once daily (on-demand regimen).
Zollinger–Ellison Syndrome: Starting dose 60 mg once daily, titrate as required.
H. pylori Eradication: 20 mg twice daily with clarithromycin 500 mg and amoxicillin 1 g twice daily for 7 days.
Pediatric GERD (1–11 yrs): 5 mg (<15 kg) or 10 mg (≥15 kg) once daily for 12 weeks.
Tablets should be swallowed whole, preferably before meals.
Rabeca may alter absorption of pH-dependent drugs (e.g., ketoconazole, itraconazole, atazanavir). No significant interaction with antacids. Avoid co-administration with atazanavir.
Generally well-tolerated. Possible effects include headache, diarrhea, abdominal pain, constipation, dry mouth, nausea, dizziness, or muscle pain.
Known hypersensitivity to rabeprazole or substituted benzimidazoles. Contraindicated in pregnancy and breastfeeding.
Rule out gastric malignancy before initiating therapy.
Long-term/high-dose PPI use may increase fracture risk (hip, wrist, spine).
Monitor for Clostridium difficile infection, hypomagnesemia, and vitamin B₁₂ deficiency during prolonged use.
Caution in hepatic impairment.
May cause mild reversible liver enzyme elevation or rare hematologic changes.
Category C. Use only if potential benefits justify potential fetal risk. Use with caution in nursing mothers.
Store below 30°C, protected from light and moisture. Keep out of children’s reach.
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